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Unicontin 400mg Tablet
Theophylline 400 is used for Asthma, Chronic obstructive pulmonary disease, Bronchospasm, Apnoea of prematurity
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Unicontin is used for:
- Managing acute asthma attacks.
- Long-term treatment of chronic asthma (both symptomatic relief and prevention).
- Controlling nighttime asthma and early morning wheezing.
- Treating chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, as well as acute COPD exacerbations.
- Managing apnea in premature infants.
Take this medication as per the advice of a registered physician.
✔️ Dosage & Administration
The dose of Theophylline should be personalized based on peak serum concentration to maximize benefits while minimizing side effects. Most sustained-release formulations are taken every 12 hours in adults, though some children may require dosing every 8 hours due to rapid metabolism. Recommended maintenance doses:
- 16 years or older: 10 mg/kg/day (maximum 900 mg/day)
- 12-15 years: 13 mg/kg/day
- 9-11 years: 16 mg/kg/day
- 1-8 years: 24 mg/kg/day
- 6 months-1 year: 12-18 mg/kg/day
- 1-6 months: 10 mg/kg/day
Take this medication as per the advice of a registered physician.
Pediatric Use: Neonates have a significantly reduced ability to clear Theophylline, requiring careful dose selection and monitoring.
✔️ Drug Interactions:
- Avoid concurrent use with other xanthine derivatives.
- Increased clearance (may require a higher dose): Barbiturates, carbamazepine, lithium, phenytoin, rifampicin, and sulphinpyrazone.
- Decreased clearance (may require a lower dose): Allopurinol, cimetidine, ciprofloxacin, corticosteroids, erythromycin, frusemide, isoprenaline, oral contraceptives, and thiabendazole.
- Theophylline may worsen hypokalemia when used with beta-2 agonists, steroids, diuretics, or in hypoxic conditions, requiring potassium level monitoring.
✔️ Contraindications:
- Hypersensitivity to Theophylline or any component of the medication.
✔️ Side effects are rare at normal doses but may include:
- Gastrointestinal discomfort
- Headache
- Nausea
- Insomnia
- Hypotension
- Central nervous system stimulation and increased urination, especially in children.
✔️ Pregnancy & Lactation:
- Theophylline’s effects on fetal health are not well established, so it should only be used during pregnancy if necessary.
- Theophylline is excreted in breast milk and may cause mild irritability or toxicity in infants. Serious effects are unlikely unless the mother has toxic Theophylline levels.
✔️ Precautions & Warnings:
- Consider potential drug interactions and physiological conditions that may affect Theophylline clearance.
- Adjust dosage carefully before starting Unicontin, before increasing the dose, and during follow-up.
- Begin with a low dose and gradually increase if tolerated.
✔️ Storage Conditions:
Store in a cool, dry place, away from light. Keep out of reach of children.
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